Molecular Assembly

We are interested in designing supramolecular systems for a wide range of biomedical and biotechnological purposes.  

We use folding and assembly mechanisms including beta-sheet fibrillization (Link to paper) and coiled-coil oligomerization (Link to paper).  Many of our technologies have been constructed from synthetic peptides (Link to paper).  Others have utilized protein expression strategies that allow for the production of proteins in a monomeric state followed by their assembly into nanofibers and gels (Link to paper and below).  

Supramolecular construction allows for the rapid generation of many different combinations and formulations of multiple factors.  Because most of the biological responses we seek to engage are highly multifactorial (e.g. immunology, cell adhesion), this modularity is extremely useful.  

 

Expressed proteins assembling into nanofibers