Modular self-assembling biomaterials for directing cellular responses.

TitleModular self-assembling biomaterials for directing cellular responses.
Publication TypeJournal Article
Year of Publication2008
AuthorsJH Collier
JournalSoft Matter
Volume4
Issue12
Start Page2310
Pagination2310 - 2315
Date Published01/2008
Abstract

Self-assembling biomaterials are promising as cell-interactive matrices because they can be constructed in a modular fashion, which enables the independent and simultaneous tuning of several of their physicochemical and biological properties. Such modularity facilitates the optimization of multi-component matrices for use in complex biological environments such as 3-D cell culture or scaffolds for regenerative medicine. This Highlight will discuss recent strategies for producing modular self-assembling biomaterials, with a particular focus on how ligand presentation and matrix mechanics can be controlled in modular ways. In addition, it will discuss key hurdles that remain for employing these materials as cell-interactive scaffolds in biomedical applications, particularly those that relate to how they may interface with the immune system.

DOI10.1039/b805563g
Short TitleSoft Matter