|Title||A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Y Wu, PK Norberg, EA Reap, KL Congdon, CN Fries, SH Kelly, JH Sampson, VP Conticello, and JH Collier|
|Journal||Acs Biomaterials Science & Engineering|
|Pagination||3128 - 3132|
A supramolecular peptide vaccine system was designed in which epitope-bearing peptides self-assemble into elongated nanofibers composed almost entirely of alpha-helical structure. The nanofibers were readily internalized by antigen presenting cells and produced robust antibody, CD4+ T-cell, and CD8+ T-cell responses without supplemental adjuvants in mice. Epitopes studied included a cancer B-cell epitope from the epidermal growth factor receptor class III variant (EGFRvIII), the universal CD4+ T-cell epitope PADRE, and the model CD8+ T-cell epitope SIINFEKL, each of which could be incorporated into supramolecular multi-epitope nanofibers in a modular fashion.
|Short Title||Acs Biomaterials Science & Engineering|