Intranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials.

TitleIntranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials.
Publication TypeJournal Article
Year of Publication2021
AuthorsB Cossette, SH Kelly, and JH Collier
JournalAcs Biomaterials Science & Engineering
Volume7
Start Page1765
Issue5
Pagination1765 - 1779
Date Published05/2021
Abstract

Intranasal vaccines offer key advantages over traditional needle-based vaccines. They are simple to administer and painless and establish local immunity at mucosal surfaces. Owing to these advantages, they are particularly attractive for use in resource-limited locations of the world. Subunit vaccines also have advantages for global distribution, as they can be engineered to be more stable to fluctuations in environmental conditions than live-attenuated or inactivated vaccines, but they tend to be poorly immunogenic intranasally. Toward realizing the potential of intranasal subunit vaccination, biomaterial-based technologies are emerging. This review provides an overview of recent progress in the preclinical development of biomaterial-based intranasal vaccines against subunit antigens and should serve as an effective introduction to the current state of this exciting field. We provide a brief overview of the obstacles facing intranasal vaccine development and identify key design criteria for consideration when designing biomaterials for intranasal subunit vaccine delivery. Promising strategies are discussed across a wide array of biomaterial classes, with a focus on selected exemplary works that highlight the considerable potential of intranasal vaccines and the biomaterial-based technologies that enable them.

DOI10.1021/acsbiomaterials.0c01291
Short TitleAcs Biomaterials Science & Engineering