A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.

TitleA Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.
Publication TypeJournal Article
Year of Publication2017
AuthorsY Wu, PK Norberg, EA Reap, KL Congdon, CN Fries, SH Kelly, JH Sampson, VP Conticello, and JH Collier
JournalAcs Biomaterials Science & Engineering
Volume3
Issue12
Start Page3128
Pagination3128 - 3132
Date Published12/2017
Abstract

A supramolecular peptide vaccine system was designed in which epitope-bearing peptides self-assemble into elongated nanofibers composed almost entirely of alpha-helical structure. The nanofibers were readily internalized by antigen presenting cells and produced robust antibody, CD4+ T-cell, and CD8+ T-cell responses without supplemental adjuvants in mice. Epitopes studied included a cancer B-cell epitope from the epidermal growth factor receptor class III variant (EGFRvIII), the universal CD4+ T-cell epitope PADRE, and the model CD8+ T-cell epitope SIINFEKL, each of which could be incorporated into supramolecular multi-epitope nanofibers in a modular fashion.

DOI10.1021/acsbiomaterials.7b00561
Short TitleAcs Biomaterials Science & Engineering