Progress Toward the Clinical Translation of Bioinspired Peptide and Protein Assemblies.

TitleProgress Toward the Clinical Translation of Bioinspired Peptide and Protein Assemblies.
Publication TypeJournal Article
Year of Publication2018
AuthorsKM Hainline, CN Fries, and JH Collier
JournalAdvanced Healthcare Materials
Volume7
Issue5
Date Published03/2018
Abstract

Supramolecular materials composed of proteins and peptides have been receiving considerable attention toward a range of diseases and conditions from vaccines to drug delivery. Owing to the relative newness of this class of materials, the bulk of work to date has been preclinical. However, examples of approved treatments particularly in vaccines, dentistry, and hemostasis demonstrate the translational potential of supramolecular polypeptides. Critical milestones in the clinical development of this class of materials and currently approved supramolecular polypeptide therapies are described in this study. Additional examples of not-yet-approved materials that are steadily advancing toward clinical use are also featured. Spherical assemblies such as virus-like particles, designed protein nanoparticles, and spherical peptide amphiphiles are highlighted, followed by fiber-forming systems such as fibrillizing peptides, fiber-forming peptide-amphiphiles, and filamentous bacteriophages.

DOI10.1002/adhm.201700930
Short TitleAdvanced Healthcare Materials