|Title||α-Helical coiled-coil peptide materials for biomedical applications.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Wu, Y, and Collier, JH|
|Journal||Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology|
Self-assembling coiled coils, which occur commonly in native proteins, have received significant interest for the design of new biomaterials-based medical therapies. Considerable effort over recent years has led to a detailed understanding of the self-assembly process of coiled coils, and a diverse collection of strategies have been developed for designing functional materials using this motif. The ability to engineer the interface between coiled coils allows one to achieve variously connected components, leading to precisely defined structures such as nanofibers, nanotubes, nanoparticles, networks, gels, and combinations of these. Currently these materials are being developed for a range of biotechnological and medical applications, including drug delivery systems for controlled release, targeted nanomaterials, 'drug-free' therapeutics, vaccine delivery systems, and others. For further resources related to this article, please visit the WIREs website.
|Short Title||Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology|