α-Helical coiled-coil peptide materials for biomedical applications.

Titleα-Helical coiled-coil peptide materials for biomedical applications.
Publication TypeJournal Article
Year of Publication2016
AuthorsY Wu, and JH Collier
JournalWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
Date Published09/2016
Abstract

Self-assembling coiled coils, which occur commonly in native proteins, have received significant interest for the design of new biomaterials-based medical therapies. Considerable effort over recent years has led to a detailed understanding of the self-assembly process of coiled coils, and a diverse collection of strategies have been developed for designing functional materials using this motif. The ability to engineer the interface between coiled coils allows one to achieve variously connected components, leading to precisely defined structures such as nanofibers, nanotubes, nanoparticles, networks, gels, and combinations of these. Currently these materials are being developed for a range of biotechnological and medical applications, including drug delivery systems for controlled release, targeted nanomaterials, 'drug-free' therapeutics, vaccine delivery systems, and others. For further resources related to this article, please visit the WIREs website.

DOI10.1002/wnan.1424
Short TitleWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology